Hybrid Biomaterials for Vascular Remodeling
This project focuses on the development of hybrid materials consisting of ECM proteins and polymer components to build a material for use in surgical reconstruction of major vessels. By incorporating site specific ECM molecules and a viable cell substrate in place of chemically crosslinked or synthetic components, we can encourage and support remodeling and regrowth in the vascular system. There are currently two main platforms: 1) a layer-built material of pericardium and biodegradable polymer, and 2) a hydrogel of ECM based material and biocompatible polymer building blocks. The goal is to engineer these materials to provide appropriate physical and biological cues that encourage natural cell infiltration and matrix remodeling from endothelial cells, myofibroblasts, and primary macrophages.